Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility

Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility

Abstract High expression of CD38 in tissues is a characteristic of aging, resulting in a decline in nicotinamide adenine dinucleotide (NAD) and increasing cellular reactive oxygen species (ROS). However, whether CD38 increases susceptibility to ferroptosis remains largely unexplored. Our previous st...

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Bibliographic Details
Main Authors: Yingying Ma, Meiqi Yi, Weixuan Wang, Xiaohui Liu, Qingtao Wang, Chongdong Liu, Yuling Chen, Haiteng Deng
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05383-7

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https://doi.org/10.1038/s41419-022-05383-7

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