PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma

PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma

Liver cancer stem cells were found to rely on glycolysis as the preferred metabolic program. Phosphoenolpyruvate carboxylase 1 (PCK1), a gluconeogenic metabolic enzyme, is down-regulated in hepatocellular carcinoma and is closely related to poor prognosis. The oncogenesis and progression of tumors a...

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Bibliographic Details
Main Authors: Rui Liu, Yi Liu, Wenlu Zhang, Guiji Zhang, Zhirong Zhang, Luyi Huang, Ni Tang, Kai Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-07-01
Series:Genes and Diseases
Subjects:
Cancer stem cells
Chemoresistance
Gluconeogenesis
Hepatocellular carcinoma
YAP
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223003975

Internet

http://www.sciencedirect.com/science/article/pii/S2352304223003975

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