Ubiquitin ligase RNF125 targets PD-L1 for ubiquitination and degradation

Ubiquitin ligase RNF125 targets PD-L1 for ubiquitination and degradation

As a critical immune checkpoint molecule, PD-L1 is expressed at significantly higher levels in multiple neoplastic tissues compared to normal ones. PD-L1/PD-1 axis is a critical target for tumor immunotherapy, blocking the PD-L1/PD-1 axis is recognized and has achieved unprecedented success in clini...

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Bibliographic Details
Main Authors: Meng Wei, Yunhai Mo, Jialong Liu, Jingtong Zhai, Huilong Li, Yixin Xu, Yumeng Peng, Zhihong Tang, Tao Wei, Xiaopan Yang, Linfei Huang, Xiao Shao, Jingfei Li, Li Zhou, Hui Zhong, Congwen Wei, Qiaosheng Xie, Min Min, Feixiang Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
RNF125
PD-L1
ubiquitination
tumor immunotherapy
clinical outcome
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.835603/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.835603/full

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