The Effects of Two Nrf2 Activators, Bardoxolone Methyl and Omaveloxolone, on Retinal Ganglion Cell Survival during Ischemic Optic Neuropathy

The Effects of Two Nrf2 Activators, Bardoxolone Methyl and Omaveloxolone, on Retinal Ganglion Cell Survival during Ischemic Optic Neuropathy

Nonarteritic anterior ischemic optic neuropathy (NAION) is one of the most common acute optic neuropathies that affect the over 55-year-old population. NAION causes the loss of visual function, and it has no safe and effective therapy. Bardoxolone methyl (methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien...

Full description

Bibliographic Details
Main Authors:	Jia-Ying Chien, Yu-Yau Chou, Jhih-Wei Ciou, Fang-Yun Liu, Shun-Ping Huang
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Antioxidants
Subjects:	ischemic optic neuropathy nuclear factor E2-related factor 2 bardoxolone methyl omaveloxolone retinal ganglion cell oxidative stress
Online Access:	https://www.mdpi.com/2076-3921/10/9/1466

Similar Items

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates
by: Reisman SA, et al.
Published: (2019-04-01)

Synthetic oleanane triterpenoids suppress MYB oncogene activity and sensitize T-cell acute lymphoblastic leukemia cells to chemotherapy
by: Paloma Tejera Nevado, et al.
Published: (2023-04-01)

Protective effects of compound M01 on retinal ganglion cells in experimental anterior ischemic optic neuropathy by inhibiting TXNIP/NLRP3 inflammasome pathway
by: Jia-Ying Chien, et al.
Published: (2023-12-01)

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo
by: Zengxin Jiang, et al.
Published: (2022-09-01)

The Protective Effects of n-Butylidenephthalide on Retinal Ganglion Cells during Ischemic Injury
by: Yu-Yau Chou, et al.
Published: (2022-02-01)

Bardoxolone methyl inhibits the infection of rabies virus via Nrf2 pathway activation in vitro
by: Ying Lin Chi, et al.
Published: (2023-11-01)

Protective Effects of Oroxylin A on Retinal Ganglion Cells in Experimental Model of Anterior Ischemic Optic Neuropathy
by: Jia-Ying Chien, et al.
Published: (2021-06-01)

Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies
by: Vittorio Porciatti, et al.
Published: (2021-06-01)

FDA Approves Omaveloxolone based on Successful Moxie Trial Results for Friedreich's Ataxia - Review
by: Krzysztof Kania, et al.
Published: (2023-08-01)

Bardoxolone methyl ameliorates osteoarthritis by inhibiting osteoclastogenesis and protecting the extracellular matrix against degradation
by: Ruijia Yang, et al.
Published: (2023-02-01)

Structural impairment patterns in peripapillary retinal fiber layer and retinal ganglion cell layer in mitochondrial optic neuropathies
by: Da Teng, et al.
Published: (2018-10-01)

Omaveloxolone approved for patients aged 16 years and older with Friedreich ataxia (FRDA): A therapeutics bulletin of the American College of Medical Genetics and Genomics (ACMG)
by: Arthur Lenahan, et al.
Published: (2023-01-01)

Cell-Based Neuroprotection of Retinal Ganglion Cells in Animal Models of Optic Neuropathies
by: Yue Hu, et al.
Published: (2021-11-01)

A Rare Cause of Compression Neuropathy of Upper Limbs – Ganglionic Cysts
by: Wai-Yin Mak
Published: (2013-06-01)

KEAP1/NRF2 as a druggable target
by: Dinkova-Kostova Albena T.
Published: (2023-01-01)

Current Landscape of NRF2 Biomarkers in Clinical Trials
by: Yoko Yagishita, et al.
Published: (2020-08-01)

Bardoxolone Methyl Ameliorates Compression-Induced Oxidative Stress Damage of Nucleus Pulposus Cells and Intervertebral Disc Degeneration Ex Vivo
by: Yueyang Tian, et al.
Published: (2022-02-01)

Erythropoietin Protects against Retinal Damage in A Rat Model of Optic Neuropathy via Glial Suppression
by: Atiyeh Eghbali, et al.
Published: (2023-05-01)

miRNA Changes in Retinal Ganglion Cells after Optic Nerve Crush and Glaucomatous Damage
by: Ben Mead, et al.
Published: (2021-06-01)

Retinal Ganglion Cells—Diversity of Cell Types and Clinical Relevance
by: Ungsoo Samuel Kim, et al.
Published: (2021-05-01)

NRF2/ARE mediated antioxidant response to glaucoma: role of glia and retinal ganglion cells
by: Sarah Naguib, et al.
Published: (2023-10-01)

Surgical Menopause Impairs Retinal Conductivity and Worsens Prognosis in an Acute Model of Rat Optic Neuropathy
by: Edyta Olakowska, et al.
Published: (2022-09-01)

Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies
by: Miao Guo, et al.
Published: (2022-12-01)

Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo
by: Pang Z, et al.
Published: (2021-09-01)

Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber’s Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells
by: Yi-Ping Yang, et al.
Published: (2019-06-01)

Ulnar Neuropathy due to Intraneural Ganglion Cyst of the Ulnar Nerve at the Elbow
by: Byung-chul Son, et al.
Published: (2018-04-01)

Application of stem cell transplantation in repair of the retinal ganglion cells injury
by: Xin Rong, et al.
Published: (2014-07-01)

The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration
by: Marita Pietrucha-Dutczak, et al.
Published: (2018-11-01)

Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology
by: Chiara La Morgia, et al.
Published: (2018-12-01)

Retinal Nerve Fibre Layer and Ganglion Cell Complex Measurement and their Correlation with Visual Field Changes among Glaucoma Patients
by: Kanika Yadav, et al.
Published: (2022-06-01)

Nrf2 Activation in Chronic Kidney Disease: Promises and Pitfalls
by: Ana Karina Aranda-Rivera, et al.
Published: (2022-06-01)

Dimethyl Fumarate Promotes the Survival of Retinal Ganglion Cells after Optic Nerve Injury, Possibly through the Nrf2/HO-1 Pathway
by: Sotaro Mori, et al.
Published: (2020-12-01)

Bardoxolone Methyl Prevents Fat Deposition and Inflammation in Brown Adipose Tissue and Enhances Sympathetic Activity in Mice Fed a High-Fat Diet
by: Chi H. L. Dinh, et al.
Published: (2015-06-01)

In vivo Regeneration of Ganglion Cells for Vision Restoration in Mammalian Retinas
by: Dongchang Xiao, et al.
Published: (2021-10-01)

Alpha retinal ganglion cells in pigmented mice retina: number and distribution
by: Alejandro Gallego-Ortega, et al.
Published: (2022-12-01)

Using Noninvasive Electrophysiology to Determine Time Windows of Neuroprotection in Optic Neuropathies
by: Vittorio Porciatti, et al.
Published: (2022-05-01)

The role of miRNA in retinal ganglion cell health and disease
by: Ben Mead, et al.
Published: (2022-01-01)

Genetic Networks in Mouse Retinal Ganglion Cells
by: Felix L Struebing, et al.
Published: (2016-09-01)

Activation of Nrf2 to Optimise Immune Responses to Intracerebral Haemorrhage
by: James J. M. Loan, et al.
Published: (2022-10-01)

Bardoxolone-Methyl (CDDO-Me) Impairs Tumor Growth and Induces Radiosensitization of Oral Squamous Cell Carcinoma Cells
by: Cornelius Hermann, et al.
Published: (2021-01-01)