Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity

Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity

CYP46A1 is a brain-specific enzyme responsible for cholesterol homeostasis. Inhibition of CYP46A1 activity serves as a therapeutic target for excitatory neurotoxicity. Sesame is a common medicine and food resource; its component lignans possess various pharmacological activities. In this study, the...

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Bibliographic Details
Main Authors: Jie Du, Xiaodong Chen, Yongshun Zhao, Tingting Zhao, Dalong Wang, Zujia Chen, Changyuan Wang, Qiang Meng, Jialin Yao, Huijun Sun, Kexin Liu, Jingjing Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
sesame lignans
CYP46A1
24S-hydroxycholesterol
NMDAR
excitatory neurotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1046814/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1046814/full

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