Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase

Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase

Guanylate binding proteins (GBPs) are soluble dynamin-like proteins that undergo a conformational transition for GTP-controlled oligomerization and disrupt membranes of intracellular parasites to exert their function as part of the innate immune system of mammalian cells. We apply neutron spin echo,...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Thomas-O Peulen, Carola S Hengstenberg, Ralf Biehl, Mykola Dimura, Charlotte Lorenz, Alessandro Valeri, Julian Folz, Christian A Hanke, Semra Ince, Tobias Vöpel, Bela Farago, Holger Gohlke, Johann P Klare, Andreas M Stadler, Claus AM Seidel, Christian Herrmann
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: eLife Sciences Publications Ltd 2023-06-01
Цуврал:eLife
Нөхцлүүд:
single-molecule fluorescence spectroscopy
electron paramagnetic resonance
small-angle x-ray scattering
neutron spin-echo spectroscopy
computer simulations
large gtpases
Онлайн хандалт:https://elifesciences.org/articles/79565

Интернэт

https://elifesciences.org/articles/79565

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