Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase

Integrative dynamic structural biology unveils conformers essential for the oligomerization of a large GTPase

Guanylate binding proteins (GBPs) are soluble dynamin-like proteins that undergo a conformational transition for GTP-controlled oligomerization and disrupt membranes of intracellular parasites to exert their function as part of the innate immune system of mammalian cells. We apply neutron spin echo,...

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Bibliographic Details
Main Authors: Thomas-O Peulen, Carola S Hengstenberg, Ralf Biehl, Mykola Dimura, Charlotte Lorenz, Alessandro Valeri, Julian Folz, Christian A Hanke, Semra Ince, Tobias Vöpel, Bela Farago, Holger Gohlke, Johann P Klare, Andreas M Stadler, Claus AM Seidel, Christian Herrmann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
single-molecule fluorescence spectroscopy
electron paramagnetic resonance
small-angle x-ray scattering
neutron spin-echo spectroscopy
computer simulations
large gtpases
Online Access:https://elifesciences.org/articles/79565

Internet

https://elifesciences.org/articles/79565

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