A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice

A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice

High rates of relapsed and refractory diffuse large B-cell lymphoma (DLBCL) patients and life-threatening side effects associated with immunochemotherapy make an urgent need to develop new therapies for DLBCL patients. Immunotoxins seem very potent anticancer therapies but their use is limited becau...

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Bibliographic Details
Main Authors: Aïda Falgàs, Annabel Garcia-León, Yáiza Núñez, Naroa Serna, Laura Sánchez-Garcia, Ugutz Unzueta, Eric Voltà-Durán, Marc Aragó, Patricia Álamo, Lorena Alba-Castellón, Jorge Sierra, Alberto Gallardo, Antonio Villaverde, Esther Vázquez, Ramon Mangues, Isolda Casanova
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Targeted-drug delivery
Nanoparticle
Diphtheria toxin
CXCR4 receptor
DLBCL
Multivalency
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222003298

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http://www.sciencedirect.com/science/article/pii/S0753332222003298

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