Decoy peptides effectively inhibit the binding of SARS-CoV-2 to ACE2 on oral epithelial cells

Decoy peptides effectively inhibit the binding of SARS-CoV-2 to ACE2 on oral epithelial cells

The entry of SARS-CoV-2 into host cells involves the interaction between the viral spike protein and the human angiotensin-converting enzyme 2 (ACE2) receptor. Given that the spike protein evolves rapidly to evade host immunity, therapeutics that block ACE2 accessibility, such as spike decoys, could...

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Bibliographic Details
Main Authors: Lai-Keng Loi, Cheng-Chieh Yang, Yu-Cheng Lin, Yee-Fun Su, Yi-Chen Juan, Yi-Hsin Chen, Hsiu-Chuan Chang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Heliyon
Subjects:
SARS-CoV-2
COVID-19
Spike protein
ACE2
Oral epithelial cell
Decoy peptide
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023098225

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