PepSim: T-cell cross-reactivity prediction via comparison of peptide sequence and peptide-HLA structure

PepSim: T-cell cross-reactivity prediction via comparison of peptide sequence and peptide-HLA structure

IntroductionPeptide-HLA class I (pHLA) complexes on the surface of tumor cells can be targeted by cytotoxic T-cells to eliminate tumors, and this is one of the bases for T-cell-based immunotherapies. However, there exist cases where therapeutic T-cells directed towards tumor pHLA complexes may also...

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Bibliographic Details
Main Authors: Sarah Hall-Swan, Jared Slone, Mauricio M. Rigo, Dinler A. Antunes, Gregory Lizée, Lydia E. Kavraki
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
T-cell cross-reactivity
peptide-HLA
immunotherapy
structure comparison
sequence similarity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1108303/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1108303/full

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