Synthetic Analogues of Aminoadamantane as Influenza Viral Inhibitors—In Vitro, In Silico and QSAR Studies

Synthetic Analogues of Aminoadamantane as Influenza Viral Inhibitors—In Vitro, In Silico and QSAR Studies

A series of nineteen amino acid analogues of amantadine (Amt) and rimantadine (Rim) were synthesized and their antiviral activity was evaluated against influenza virus A (H3N2). Among these analogues, the conjugation of rimantadine with glycine illustrated high antiviral activity combined with low c...

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Bibliographic Details
Main Authors: Radoslav Chayrov, Nikolaos A. Parisis, Maria V. Chatziathanasiadou, Eleni Vrontaki, Kalliopi Moschovou, Georgia Melagraki, Hristina Sbirkova-Dimitrova, Boris Shivachev, Michaela Schmidtke, Yavor Mitrev, Martin Sticha, Thomas Mavromoustakos, Andreas G. Tzakos, Ivanka Stankova
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
adamantane derivatives
amino acids
3D-QSAR
molecular docking
X-Ray crystallography
plasma stability
Online Access:https://www.mdpi.com/1420-3049/25/17/3989

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https://www.mdpi.com/1420-3049/25/17/3989

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