Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

Abstract Background Microglial polarization with M1/M2 phenotype shifts and the subsequent neuroinflammatory responses are vital contributing factors for spinal cord injury (SCI)-induced secondary injury. Nuclear factor-κB (NF-κB) is considered the central transcription factor of inflammatory mediat...

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Bibliographic Details
Main Authors: Shoubo Chen, Jingfang Ye, Xiangrong Chen, Jinnan Shi, Wenhua Wu, Wenping Lin, Weibin Lin, Yasong Li, Huangde Fu, Shun Li
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Spinal cord injury
Valproic acid
HDAC3
Microglia
Inflammatory
STAT1
Online Access:http://link.springer.com/article/10.1186/s12974-018-1193-6

Internet

http://link.springer.com/article/10.1186/s12974-018-1193-6

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