Homocysteine-induced endoplasmic reticulum stress activates FGF21 and is associated with browning and atrophy of white adipose tissue in Bhmt knockout mice

Homocysteine-induced endoplasmic reticulum stress activates FGF21 and is associated with browning and atrophy of white adipose tissue in Bhmt knockout mice

Betaine-homocysteine methyltransferase (BHMT) catalyzes the transfer of methyl groups from betaine to homocysteine (Hcy), producing methionine and dimethylglycine. In this work, we characterize Bhmt wild type (Bhmt-WT) and knockout (Bhmt-KO) mice that were fully backcrossed to a C57Bl6/J background....

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Bibliographic Details
Main Authors: Manya Warrier, Evan M. Paules, Jorge Silva-Gomez, Walter B. Friday, Frances Bramlett, Hyunbae Kim, Kezhong Zhang, Isis Trujillo-Gonzalez
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Heliyon
Subjects:
Betaine-homocysteine S-Methyltransferase
Lipodystrophy
ER stress
CREBH
BHMT
FGF21
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023004231

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http://www.sciencedirect.com/science/article/pii/S2405844023004231

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