Neuroprotective Effects of Sodium Butyrate and Monomethyl Fumarate Treatment through GPR109A Modulation and Intestinal Barrier Restoration on PD Mice

Neuroprotective Effects of Sodium Butyrate and Monomethyl Fumarate Treatment through GPR109A Modulation and Intestinal Barrier Restoration on PD Mice

Research has connected Parkinson’s disease (PD) with impaired intestinal barrier. The activation of G-protein-coupled receptor 109A (GPR109A) protects the intestinal barrier by inhibiting the NF-κB signaling pathway. Sodium butyrate (NaB), which is a GPR109A ligand, may have anti-PD effects. The cur...

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Bibliographic Details
Main Authors: Rui-Chen Xu, Wen-Teng Miao, Jing-Yi Xu, Wen-Xin Xu, Ming-Ran Liu, Song-Tao Ding, Yu-Xin Jian, Yi-Han Lei, Ning Yan, Han-Deng Liu
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Nutrients
Subjects:
Parkinson’s disease
intestinal barrier
sodium butyrate
GPR109A receptor
monomethyl fumarate
Online Access:https://www.mdpi.com/2072-6643/14/19/4163

Internet

https://www.mdpi.com/2072-6643/14/19/4163

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