Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage

Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage

Abstract Background N-acetyltransferase 10 (NAT10), an abundant nucleolar protein with both lysine and RNA cytidine acetyltransferase activities, has been implicated in Hutchinson-Gilford progeria syndrome and human cancer. We and others recently demonstrated that NAT10 is translocated from the nucl...

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Bibliographic Details
Main Authors: Hong-Yi Liu, Ying-Ying Liu, Yin-Ling Zhang, Yan Ning, Fang-Lin Zhang, Da-Qiang Li
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Cell Communication and Signaling
Subjects:
DNA damage response
Nucleoplasmic translocation
Nucleolar localization signal
Posttranslational modification
PARylation
Online Access:https://doi.org/10.1186/s12964-022-00932-1

Internet

https://doi.org/10.1186/s12964-022-00932-1

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