Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma

Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with 2 etiologies. Merkel cell polyomavirus (MCPyV) integration is present in about 80% of all MCC. Virus-positive MCC (MCCP) tumors have few somatic mutations and usually express WT p53 (TP53). By contrast, virus-nega...

Full description

Bibliographic Details
Main Authors: Varsha Ananthapadmanabhan, Thomas C. Frost, Kara M. Soroko, Aine Knott, Brianna J. Magliozzi, Prafulla C. Gokhale, Vijaya G. Tirunagaru, Robert C. Doebele, James A. DeCaprio
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-07-01
Series:JCI Insight
Subjects:
Oncology
Therapeutics
Online Access:https://doi.org/10.1172/jci.insight.160513

Internet

https://doi.org/10.1172/jci.insight.160513

Similar Items