Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy

Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy

Abstract Background Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of chemotherapy with poorly understood mechanisms and few treatments. High-mobility group box 1 (HMGB1)-induced neuroinflammation is the main cause of CIPN. Here, we aimed to illustrate the role of the mac...

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Bibliographic Details
Main Authors: Xing Yang, Rumeng Jia, Fan Hu, Wen Fan, Tongtong Lin, Xiaotao Zhang, Chenjie Xu, Shirong Ruan, Chunyi Jiang, Yan Li, Cailong Pan, Yang Yang, Liang Hu, Qi Chen, Wen-Tao Liu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Cell Communication and Signaling
Subjects:
Macrophage
Clearance
SR-A1
HMGB1
CIPN
Online Access:https://doi.org/10.1186/s12964-023-01100-9

Internet

https://doi.org/10.1186/s12964-023-01100-9

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