Design of modular gellan gum hydrogel functionalized with avidin and biotinylated adhesive ligands for cell culture applications.

This article proposes the coupling of the recombinant protein avidin to the polysaccharide gellan gum to create a modular hydrogel substrate for 3D cell culture and tissue engineering. Avidin is capable of binding biotin, and thus biotinylated compounds can be tethered to the polymer network to impr...

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Bibliographic Details
Main Authors: Christine Gering, Janne T Koivisto, Jenny Parraga, Jenni Leppiniemi, Kaisa Vuornos, Vesa P Hytönen, Susanna Miettinen, Minna Kellomäki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221931