Kinetic model of DNA double-strand break repair in primary human fibroblasts exposed to low-LET irradiation with various dose rates

Kinetic model of DNA double-strand break repair in primary human fibroblasts exposed to low-LET irradiation with various dose rates

Here we demonstrate the results of kinetic modeilng of DNA double-strand breaks induction and repair and phosphorilated histone H2AX ($\gamma$-H2AX) and Rad51 foci formation in primary human fibroblasts exposed to low-LET ionizing radiation (IR). The model describes two major paths of DNA double-str...

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Bibliographic Details
Main Authors: Ivan Vitalievich Ozerov, Andreyan Nikolaevich Osipov
Format: Article
Language:Russian
Published: Institute of Computer Science 2015-02-01
Series:Компьютерные исследования и моделирование
Subjects:
DNA double-strand breaks
DNA repair
kinetic modeling
low-LET ionizing radiation
dose rate
Online Access:http://crm.ics.org.ru/uploads/crmissues/crm_2015_1/15112.pdf

Internet

http://crm.ics.org.ru/uploads/crmissues/crm_2015_1/15112.pdf

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