Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis

Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis

Abstract Background Disruption of β-amyloid (Aβ) homeostasis is the initial culprit in Alzheimer’s disease (AD) pathogenesis. Astrocytes respond to emerging Aβ plaques by altering their phenotype and function, yet molecular mechanisms governing astrocytic response and their precise role in counterin...

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Bibliographic Details
Main Authors: Joanna E. Pankiewicz, Jenny R. Diaz, Mitchell Martá-Ariza, Anita M. Lizińczyk, Leor A. Franco, Martin J. Sadowski
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Molecular Neurodegeneration
Subjects:
Astrocytes
Alzheimer’s disease
β-Amyloid plaques
Microglia
Neurodegeneration
Peroxiredoxin 6
Online Access:http://link.springer.com/article/10.1186/s13024-020-00401-8

Internet

http://link.springer.com/article/10.1186/s13024-020-00401-8

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