TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis

TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis

Summary: Long bones are generated by mesoderm-derived skeletal progenitor/stem cells (SSCs) through endochondral ossification, a process of sequential chondrogenic and osteogenic differentiation tightly controlled by the synergy between intrinsic and microenvironment cues. Here, we report that loss...

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Bibliographic Details
Main Authors: Huadie Liu, Ye Liu, Seung-Gi Jin, Jennifer Johnson, Hongwen Xuan, Di Lu, Jianshuang Li, Lukai Zhai, Xianfeng Li, Yaguang Zhao, Minmin Liu, Sonya E.L. Craig, Joseph S. Floramo, Vladimir Molchanov, Jie Li, Jia-Da Li, Connie Krawczyk, Xiaobing Shi, Gerd P. Pfeifer, Tao Yang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cell Reports
Subjects:
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723000232

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http://www.sciencedirect.com/science/article/pii/S2211124723000232

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