Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination

The Fanconi anemia (FA) DNA repair pathway coordinates a faithful repair mechanism for stalled DNA replication forks caused by factors such as DNA interstrand crosslinks (ICLs) or replication stress. An important role of FA pathway activation is initiated by monoubiquitination of FANCD2 and its bind...

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Bibliographic Details
Main Author: Masamichi Ishiai
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/12/11/1763