Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination
The Fanconi anemia (FA) DNA repair pathway coordinates a faithful repair mechanism for stalled DNA replication forks caused by factors such as DNA interstrand crosslinks (ICLs) or replication stress. An important role of FA pathway activation is initiated by monoubiquitination of FANCD2 and its bind...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/11/1763 |
| _version_ | 1797510215673839616 |
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| author | Masamichi Ishiai |
| author_facet | Masamichi Ishiai |
| author_sort | Masamichi Ishiai |
| collection | DOAJ |
| description | The Fanconi anemia (FA) DNA repair pathway coordinates a faithful repair mechanism for stalled DNA replication forks caused by factors such as DNA interstrand crosslinks (ICLs) or replication stress. An important role of FA pathway activation is initiated by monoubiquitination of FANCD2 and its binding partner of FANCI, which is regulated by the ATM-related kinase, ATR. Therefore, regulation of the FA pathway is a good example of the contribution of ATR to genome stability. In this short review, we summarize the knowledge accumulated over the years regarding how the FA pathway is activated via phosphorylation and monoubiquitination. |
| first_indexed | 2024-03-10T05:28:25Z |
| format | Article |
| id | doaj.art-48fb5e63ca36405db9f5bb01e9b0345c |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T05:28:25Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-48fb5e63ca36405db9f5bb01e9b0345c2023-11-22T23:28:27ZengMDPI AGGenes2073-44252021-11-011211176310.3390/genes12111763Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and MonoubiquitinationMasamichi Ishiai0Central Radioisotope Division, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104-0045, JapanThe Fanconi anemia (FA) DNA repair pathway coordinates a faithful repair mechanism for stalled DNA replication forks caused by factors such as DNA interstrand crosslinks (ICLs) or replication stress. An important role of FA pathway activation is initiated by monoubiquitination of FANCD2 and its binding partner of FANCI, which is regulated by the ATM-related kinase, ATR. Therefore, regulation of the FA pathway is a good example of the contribution of ATR to genome stability. In this short review, we summarize the knowledge accumulated over the years regarding how the FA pathway is activated via phosphorylation and monoubiquitination.https://www.mdpi.com/2073-4425/12/11/1763Fanconi anemiaubiquitinationphosphorylationATRATMinterstrand crosslink |
| spellingShingle | Masamichi Ishiai Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination Genes Fanconi anemia ubiquitination phosphorylation ATR ATM interstrand crosslink |
| title | Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination |
| title_full | Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination |
| title_fullStr | Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination |
| title_full_unstemmed | Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination |
| title_short | Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination |
| title_sort | regulation of the fanconi anemia dna repair pathway by phosphorylation and monoubiquitination |
| topic | Fanconi anemia ubiquitination phosphorylation ATR ATM interstrand crosslink |
| url | https://www.mdpi.com/2073-4425/12/11/1763 |
| work_keys_str_mv | AT masamichiishiai regulationofthefanconianemiadnarepairpathwaybyphosphorylationandmonoubiquitination |