LTB4 and 5-oxo-ETE from extracellular vesicles stimulate neutrophils in granulomatosis with polyangiitis

LTB4 and 5-oxo-ETE from extracellular vesicles stimulate neutrophils in granulomatosis with polyangiitis

Activation of neutrophils is an important mechanism in the pathology of granulomatosis with polyangiitis (GPA). In this study, we evaluated whether extracellular vesicles (EVs) circulating in the plasma of GPA patients could contribute to this process. EVs from the plasma of GPA patients in the acti...

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Bibliographic Details
Main Authors: Marcin Surmiak, Anna Gielicz, Darko Stojkov, Rafał Szatanek, Katarzyna Wawrzycka-Adamczyk, Shida Yousefi, Hans-Uwe Simon, Marek Sanak
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Lipid Research
Subjects:
neutrophil extracellular traps
reactive oxygen species
immunology
inflammation
eicosanoids
leukotrienes
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520300110

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http://www.sciencedirect.com/science/article/pii/S0022227520300110

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