Synthesis of Hybrid Molecules with Imidazole-1,3,4-thiadiazole Core and Evaluation of Biological Activity on <i>Trypanosoma cruzi</i> and <i>Leishmania donovani</i>

Synthesis of Hybrid Molecules with Imidazole-1,3,4-thiadiazole Core and Evaluation of Biological Activity on <i>Trypanosoma cruzi</i> and <i>Leishmania donovani</i>

The aim of this work was to obtain and evaluate, as antiprotozoals, new derivatives of benzoate imidazo-1,3,4-thiadiazole <b>18</b>–<b>23</b> based on the concepts of molecular repositioning and hybridization. In the design of these compounds, two important pharmacophoric sub...

Full description

Bibliographic Details
Main Authors: Ali Mijoba, Nereida Parra-Giménez, Esteban Fernandez-Moreira, Hegira Ramírez, Xenón Serrano, Zuleima Blanco, Sandra Espinosa, Jaime E. Charris
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Molecules
Subjects:
nitroimidazole
thiadiazole
hybridization
<i>T. cruzi</i>
<i>L. donovani</i>
Online Access:https://www.mdpi.com/1420-3049/29/17/4125

Internet

https://www.mdpi.com/1420-3049/29/17/4125

Similar Items