Molecular features that predict the response to antimetabolite chemotherapies

Abstract Background Antimetabolite chemotherapeutic agents that target cellular metabolism are widely used in the clinic and are thought to exert their anti-cancer effects mainly through non-specific cytotoxic effects. However, patients vary dramatically with respect to treatment outcome, and the so...

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Bibliographic Details
Main Authors: Mahya Mehrmohamadi, Seong Ho Jeong, Jason W. Locasale
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Cancer & Metabolism
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40170-017-0170-3