Synthesis and Biological Evaluation of Novel 6-Hydroxy-benzo[d][1,3]oxathiol-2-one Schiff Bases as Potential Anticancer Agents

Synthesis and Biological Evaluation of Novel 6-Hydroxy-benzo[d][1,3]oxathiol-2-one Schiff Bases as Potential Anticancer Agents

With the aim of discovering new anticancer agents, we have designed and synthesized novel 6-hydroxy-benzo[d][1,3]oxathiol-2-one Schiff bases. The synthesis started with the selective nitration at 5-position of 6-hydroxybenzo[d][1,3]oxathiol-2-one (1) leading to the nitro derivative 2. The nitro grou...

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Bibliographic Details
Main Authors: Eliza de Lucas Chazin, Paola de Souza Sanches, Eric Brazil Lindgren, Walcimar Trindade Vellasco Júnior, Laine Celestino Pinto, Rommel Mario Rodríguez Burbano, Julliane Diniz Yoneda, Kátia Zaccur Leal, Claudia Regina Brandão Gomes, James Lewis Wardell, Solange Maria Silva Veloso Wardell, Raquel Carvalho Montenegro, Thatyana Rocha Alves Vasconcelos
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Molecules
Subjects:
1,3-benzoxathiol-2-ones
Schiff bases
anticancer
X-ray diffraction
Lipinski’s rule of five
Online Access:http://www.mdpi.com/1420-3049/20/2/1968

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http://www.mdpi.com/1420-3049/20/2/1968

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