Fungal statin pump protein improves monacolin J efflux and regulates its production in Komagataella phaffii

Fungal statin pump protein improves monacolin J efflux and regulates its production in Komagataella phaffii

Abstract Background Monacolin J (MJ) is a key intermediate for the synthesis of cholesterol-lowering drug simvastatin. Current industrial production of MJ involves complicated chemical hydrolysis of microbial fermented lovastatin. Recently, heterologous production of MJ has been achieved in yeast an...

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Bibliographic Details
Main Authors: Chenxiao Bai, Yiqi Liu, Xinjie Chen, Zhilan Qian, Haifeng Liu, Xiangshan Zhou, Yuanxing Zhang, Menghao Cai
Format: Article
Language:English
Published: SpringerOpen 2020-06-01
Series:Bioresources and Bioprocessing
Subjects:
Statin pump protein
Komagataella phaffii
Monacolin J
Metabolite efflux
Online Access:http://link.springer.com/article/10.1186/s40643-020-00321-x

Internet

http://link.springer.com/article/10.1186/s40643-020-00321-x

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