Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism

Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism

The obstruction of post-insulin receptor signaling is the main mechanism of insulin-resistant diabetes. Progestin and adipoQ receptor 3 (PAQR3), a key regulator of inflammation and metabolism, can negatively regulate the PI3K/AKT signaling pathway. Here, we report that gentiopicroside (GPS), the mai...

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Bibliographic Details
Main Authors: Haiming Xiao, Xiaohong Sun, Zeyuan Lin, Yan Yang, Meng Zhang, Zhanchi Xu, Peiqing Liu, Zhongqiu Liu, Heqing Huang
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Gentiopicroside
Insulin resistance
PAQR3
PI3K/AKT
DDB2
Ubiquitylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521004949

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http://www.sciencedirect.com/science/article/pii/S2211383521004949

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