Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications

Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications

In this review, we explore how short-chain fatty acids (SCFAs) produced by the gut microbiome affect Parkinson's disease (PD) through their modulatory interactions with alpha-synuclein, neuroinflammation, and oxidative stress mediated by reactive oxygen and nitrogen species (ROS/RNS). In partic...

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Bibliographic Details
Main Authors: Balaraman Kalyanaraman, Gang Cheng, Micael Hardy
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Redox Biology
Subjects:
Short-chain fatty acid (SCFA)
Butyrate
Alpha-synuclein
Parkinson's disease
Reactive oxygen/nitrogen species
Gut microbiome
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000685

Internet

http://www.sciencedirect.com/science/article/pii/S2213231724000685

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