Two intestinal microbiota-derived metabolites, deoxycholic acid and butyrate, synergize to enhance host defense peptide synthesis and alleviate necrotic enteritis

Two intestinal microbiota-derived metabolites, deoxycholic acid and butyrate, synergize to enhance host defense peptide synthesis and alleviate necrotic enteritis

Abstract Background Necrotic enteritis (NE) is a major enteric disease in poultry, yet effective mitigation strategies remain elusive. Deoxycholic acid (DCA) and butyrate, two major metabolites derived from the intestinal microbiota, have independently been shown to induce host defense peptide (HDP)...

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Bibliographic Details
Main Authors: Dohyung M. Kim, Jing Liu, Melanie A. Whitmore, Isabel Tobin, Zijun Zhao, Guolong Zhang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Animal Science and Biotechnology
Subjects:
Bile acids
Host defense peptides
Metabolites
Microbiome
Necrotic enteritis
Short-chain fatty acids
Online Access:https://doi.org/10.1186/s40104-024-00995-9

Internet

https://doi.org/10.1186/s40104-024-00995-9

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