The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region

The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region

Abstract The Human Leucocyte Antigen (HLA) locus and other DNA sequence variants identified in Genome-Wide Association (GWA) studies explain around 50% of the heritability of celiac disease (CD). However, the pathogenesis of CD could be driven by other layers of genomic information independent from...

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Bibliographic Details
Main Authors: Nora Fernandez-Jimenez, Koldo Garcia-Etxebarria, Leticia Plaza-Izurieta, Irati Romero-Garmendia, Amaia Jauregi-Miguel, Maria Legarda, Szilvia Ecsedi, Ainara Castellanos-Rubio, Vincent Cahais, Cyrille Cuenin, Davide Degli Esposti, Iñaki Irastorza, Hector Hernandez-Vargas, Zdenko Herceg, Jose Ramon Bilbao
Format: Article
Language:English
Published: Nature Portfolio 2019-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-37746-6

Internet

https://doi.org/10.1038/s41598-018-37746-6

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