Broadening our understanding of genetic risk for scleroderma/systemic sclerosis by querying the chromatin architecture surrounding the risk haplotypes

Abstract Background Genetic variants in the human leukocyte antigen (HLA) locus contribute to the risk for developing scleroderma/systemic sclerosis (SSc). However, there are other replicated loci that also contribute to genetic risk for SSc, and it is unknown whether genetic risk in these non-HLA l...

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Bibliographic Details
Main Authors: Kerry E. Poppenberg, Vincent M. Tutino, Evan Tarbell, James N. Jarvis
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Medical Genomics
Subjects:
Online Access:https://doi.org/10.1186/s12920-021-00964-5