Non-Oncogene Addiction of <i>KRAS</i>-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ

Non-Oncogene Addiction of <i>KRAS</i>-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ

<i>Kirsten rat sarcoma virus (KRAS)</i>-mutant cancers are frequent, metastatic, lethal, and largely undruggable. While interleukin (IL)-1β and nuclear factor (NF)-κB inhibition hold promise against cancer, untargeted treatments are not effective. Here, we show that human <i>KRAS&l...

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Bibliographic Details
Main Authors: Magda Spella, Giannoula Ntaliarda, Georgios Skiadas, Anne-Sophie Lamort, Malamati Vreka, Antonia Marazioti, Ioannis Lilis, Eleni Bouloukou, Georgia A. Giotopoulou, Mario A. A. Pepe, Stefanie A. I. Weiss, Agnese Petrera, Stefanie M. Hauck, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Kristina A. M. Arendt, Ioanna Giopanou, David Brunn, Rajkumar Savai, Dieter E. Jenne, Maarten de Château, Fiona E. Yull, Timothy S. Blackwell, Georgios T. Stathopoulos
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
nuclear factor-κB
interleukin-1β
cancer
inflammation
non-oncogene addiction
bioluminescence
Online Access:https://www.mdpi.com/2072-6694/15/6/1866

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https://www.mdpi.com/2072-6694/15/6/1866

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