Structural basis of dynamic P5CS filaments

Structural basis of dynamic P5CS filaments

The bifunctional enzyme Δ1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture. Pathogenic mutations in the P5CS gene (ALDH18A1) lead to neurocutaneous syndrome and skin relaxation connective tissue dis...

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Bibliographic Details
Main Authors: Jiale Zhong, Chen-Jun Guo, Xian Zhou, Chia-Chun Chang, Boqi Yin, Tianyi Zhang, Huan-Huan Hu, Guang-Ming Lu, Ji-Long Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
P5CS
cytoophidium
proline synthesis
Drosophila
Cryo-EM
metabolic enzyme
Online Access:https://elifesciences.org/articles/76107

Internet

https://elifesciences.org/articles/76107

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