A rho GDP dissociation inhibitor produced by apoptotic T-cells inhibits growth of Mycobacterium tuberculosis.

A rho GDP dissociation inhibitor produced by apoptotic T-cells inhibits growth of Mycobacterium tuberculosis.

In this study, we found that a subpopulation of CD4(+)CD25(+) (85% Foxp3(+)) cells from persons with latent tuberculosis infection (LTBI) inhibits growth of M. tuberculosis (M. tb) in human monocyte-derived macrophages (MDMs). A soluble factor, Rho GDP dissociation inhibitor (D4GDI), produced by apo...

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Bibliographic Details
Main Authors: Sambasivan Venkatasubramanian, Rohan Dhiman, Padmaja Paidipally, Satyanarayana S Cheekatla, Deepak Tripathi, Elwyn Welch, Amy R Tvinnereim, Brenda Jones, Dan Theodorescu, Peter F Barnes, Ramakrishna Vankayalapati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4450061?pdf=render

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http://europepmc.org/articles/PMC4450061?pdf=render

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