Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

BackgroundTrimethylamine‐N‐oxide (TMAO) has recently been identified as a novel and independent risk factor for promoting atherosclerosis through inducing vascular inflammation. However, the exact mechanism is currently unclear. Studies have established a central role of nucleotide‐binding oligomeri...

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Bibliographic Details
Main Authors: Ming‐liang Chen, Xiao‐hui Zhu, Li Ran, He‐dong Lang, Long Yi, Man‐tian Mi
Format: Article
Language:English
Published: Wiley 2017-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atherosclerosis
NOD‐like receptor family pyrin domain containing 3 inflammasome
sirtuin 3
trimethylamine‐N‐oxide
vascular inflammation
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.006347

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.006347

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