Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41in renal cells.

Bibliographic Details
Main Authors: Pierre Bigot, Leandro M. Colli, Mitchell J. Machiela, Lea Jessop, Timothy A. Myers, Julie Carrouget, Sarah Wagner, David Roberson, Caroline Eymerit, Daniel Henrion, Stephen J. Chanock
Format: Article
Language:English
Published: Nature Portfolio 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12098

Internet

https://doi.org/10.1038/ncomms12098

Similar Items