Inhibitory Activity of 4-Benzylidene Oxazolones Derivatives of Cinnamic Acid on Human Acetylcholinesterase and Cognitive Improvements in a Mouse Model

Inhibitory Activity of 4-Benzylidene Oxazolones Derivatives of Cinnamic Acid on Human Acetylcholinesterase and Cognitive Improvements in a Mouse Model

We synthesized seven (<i>Z</i>)-benzylidene-2-(<i>E</i>)-styryloxazol-5(4<i>H</i>)-ones derivatives of cinnamic acid and evaluated the ability of these compounds to inhibit human acetylcholinesterase (hAChE). The most potent compound was evaluated for cognitive im...

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Bibliographic Details
Main Authors: Alma Marisol Ramírez-Ruiz, Martha Elena Ávila-Cossío, Arturo Estolano-Cobián, José Manuel Cornejo-Bravo, Ana Laura Martinez, Iván Córdova-Guerrero, Bibiana Roselly Cota-Ramírez, Krysta Paola Carranza-Ambriz, Ignacio A. Rivero, Aracely Serrano-Medina
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
oxazolones
cinnamic acid
human acetylcholinesterase
inhibitory activity
Online Access:https://www.mdpi.com/1420-3049/28/21/7392

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https://www.mdpi.com/1420-3049/28/21/7392

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