Intravitreal Neuroglobin Mitigates Primate Experimental Glaucomatous Structural Damage in Association with Reduced Optic Nerve Microglial and Complement 3-Astrocyte Activation

Intravitreal Neuroglobin Mitigates Primate Experimental Glaucomatous Structural Damage in Association with Reduced Optic Nerve Microglial and Complement 3-Astrocyte Activation

Current management of glaucomatous optic neuropathy is limited to intraocular pressure control. Neuroglobin (Ngb) is an endogenous neuroprotectant expressed in neurons and astrocytes. We recently showed that exogenous intravitreal Ngb reduced inflammatory cytokines and microglial activation in a rod...

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Bibliographic Details
Main Authors: Anita S. Y. Chan, Sai B. B. Tun, Myoe N. Lynn, Candice Ho, Tin A. Tun, Michaël J. A. Girard, Rehena Sultana, Veluchamy A. Barathi, Tin Aung, Makoto Aihara
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomolecules
Subjects:
glaucomatous optic neuropathy
neuroglobin
complement 3
astrogliosis
microgliosis
neuroprotection
Online Access:https://www.mdpi.com/2218-273X/13/6/961

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https://www.mdpi.com/2218-273X/13/6/961

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