MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity

MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity

H-type endothelium, defined by the high expression of CD31 and endomucin, is found in the bone where it promotes angiogenesis and osteogensis. Here Yanget al. show that the miR-497∼195 cluster regulates the generation and maintenance of the H-type endothelium by controlling the levels of Notch regul...

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Bibliographic Details
Main Authors: Mi Yang, Chang-Jun Li, Xi Sun, Qi Guo, Ye Xiao, Tian Su, Man-Li Tu, Hui Peng, Qiong Lu, Qing Liu, Hong-Bo He, Tie-Jian Jiang, Min-Xiang Lei, Mei Wan, Xu Cao, Xiang-Hang Luo
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms16003

Internet

https://doi.org/10.1038/ncomms16003

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