BI-847325, a selective dual MEK and Aurora kinases inhibitor, reduces aggressive behavior of anaplastic thyroid carcinoma on an in vitro three-dimensional culture

BI-847325, a selective dual MEK and Aurora kinases inhibitor, reduces aggressive behavior of anaplastic thyroid carcinoma on an in vitro three-dimensional culture

Abstract Background Anaplastic thyroid carcinoma (ATC) is the most aggressive subtype of thyroid cancer. In this study, we used a three-dimensional in vitro system to evaluate the effect of a dual MEK/Aurora kinase inhibitor, BI-847325 anticancer drug, on several cellular and molecular processes inv...

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Bibliographic Details
Main Authors: Hilda Samimi, Rezvan Tavakoli, Parviz Fallah, Alireza Naderi Sohi, Maryam Amini Shirkouhi, Mahmood Naderi, Vahid Haghpanah
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cancer Cell International
Subjects:
Anaplastic thyroid carcinoma
BI-847325
MEK
Aurora kinase
Online Access:https://doi.org/10.1186/s12935-022-02813-6

Internet

https://doi.org/10.1186/s12935-022-02813-6

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