Dual epigenetic changes in diabetes mellitus‐associated pancreatic ductal adenocarcinoma correlate with downregulation of E‐cadherin and worsened prognosis

Dual epigenetic changes in diabetes mellitus‐associated pancreatic ductal adenocarcinoma correlate with downregulation of E‐cadherin and worsened prognosis

Abstract Diabetes mellitus (DM) is a risk factor for pancreatic ductal adenocarcinoma (PDAC) that promotes the promoter methylation of CDH1. It is still unclear whether DM can exert other epigenetic effects, such as altering microRNA (miR) expression, in PDAC. The expression of miR‐100‐5p is known t...

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Bibliographic Details
Main Authors: Yutaro Hara, Hiroki Mizukami, Keisuke Yamazaki, Takahiro Yamada, Akiko Igawa, Yuki Takeuchi, Takanori Sasaki, Hanae Kushibiki, Kotaro Murakami, Kazuhiro Kudoh, Keinosuke Ishido, Kenichi Hakamada
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:The Journal of Pathology: Clinical Research
Subjects:
diabetes mellitus
pancreatic ductal adenocarcinoma
promoter methylation
microRNA
E‐cadherin
Online Access:https://doi.org/10.1002/cjp2.326

Internet

https://doi.org/10.1002/cjp2.326

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