A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML

A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML

Translocations of the KMT2A (MLL) gene define a biologically distinct and clinically aggressive subtype of acute myeloid leukaemia (AML), marked by a characteristic gene expression profile and few cooperating mutations. Although dysregulation of the epigenetic landscape in this leukaemia is particul...

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Bibliographic Details
Main Authors: Michael A. Koldobskiy, Jordi Abante, Garrett Jenkinson, Elisabet Pujadas, Ashley Tetens, Feifei Zhao, Rakel Tryggvadottir, Adrian Idrizi, Andreas Reinisch, Ravindra Majeti, John Goutsias, Andrew P. Feinberg
Format: Article
Language:English
Published: Taylor & Francis Group 2020-08-01
Series:Epigenetics
Subjects:
leukaemia
dna methylation
dna methylation stochasticity
Online Access:http://dx.doi.org/10.1080/15592294.2020.1734149

Internet

http://dx.doi.org/10.1080/15592294.2020.1734149

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