Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling

Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling

Osteosarcomas are frequently associated to a poor prognosis and a modest response to current treatments. EC-8042 is a well-tolerated mithramycin analog that has demonstrated an efficient ability to eliminate tumor cells, including cancer stem cell subpopulations (CSC), in sarcomas. In transcriptomic...

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Bibliographic Details
Main Authors: Óscar Estupiñán, Verónica Rey, Juan Tornín, Dzohara Murillo, Borja Gallego, Carmen Huergo, Verónica Blanco-Lorenzo, M. Victoria González, Aida Rodríguez, Francisco Moris, Jessica González, Verónica Ayllón, Verónica Ramos-Mejía, Anna Bigas, René Rodríguez
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
NOTCH1
HES1
EC-8042
Mithramycin
Sarcoma
Osteosarcoma
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223004158

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http://www.sciencedirect.com/science/article/pii/S0753332223004158

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