Apoptosis-related gene expression can predict the response of ovarian cancer cell lines to treatment with recombinant human TRAIL alone or combined with cisplatin

Apoptosis-related gene expression can predict the response of ovarian cancer cell lines to treatment with recombinant human TRAIL alone or combined with cisplatin

OBJECTIVES: The objectives of this study were to determine the sensitivity of ovarian cancer (OC) cell lines (TOV-21G and SKOV-3) to cisplatin and to the recombinant human TRAIL (rhTRAIL), and to evaluate the expression profile of TNFRSF10B, TNFRSF10C, TP53TG5, MDM2, BAX, BCL-2 and CASPASE-8 genes a...

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Bibliographic Details
Main Authors: Letícia da Conceição Braga, Nikole Gontijo Gonçales, Rafaela de Souza Furtado, Warne Pedro de Andrade, Luciana Maria Silva, Agnaldo Lopes da Silva Filho
Format: Article
Language:English
Published: Elsevier España 2020-03-01
Series:Clinics
Subjects:
Ovarian Cancer
Gene Expression
Chemoresistance
Apoptosis
Trail
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100219&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322020000100219&tlng=en

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