A chemogenomic approach is required for effective treatment of amyotrophic lateral sclerosis

A chemogenomic approach is required for effective treatment of amyotrophic lateral sclerosis

Abstract ALS is a fatal untreatable disease involving degeneration of motor neurons. Μultiple causative genes encoding proteins with versatile functions have been identified indicating that diverse biological pathways lead to ALS. Chemical entities still represent a promising choice to delay ALS pro...

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Bibliographic Details
Main Authors: Georgios Pampalakis, Georgios Angelis, Eleni Zingkou, Kostas Vekrellis, Georgia Sotiropoulou
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Clinical and Translational Medicine
Subjects:
amyotrophic lateral sclerosis (ALS)
animal models
chemogenomics
disease heterogeneity
small molecules
stratification
Online Access:https://doi.org/10.1002/ctm2.657

Internet

https://doi.org/10.1002/ctm2.657

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