Inhibitory Activity of Natural <i>cis</i>-Khellactone on Soluble Epoxide Hydrolase and Proinflammatory Cytokine Production in Lipopolysaccharides-Stimulated RAW264.7 Cells

Inhibitory Activity of Natural <i>cis</i>-Khellactone on Soluble Epoxide Hydrolase and Proinflammatory Cytokine Production in Lipopolysaccharides-Stimulated RAW264.7 Cells

The pursuit of anti-inflammatory agents has led to intensive research on the inhibition of soluble epoxide hydrolase (sEH) and cytokine production using medicinal plants. In this study, we evaluated the efficacy of <i>cis</i>-khellactone, a compound isolated for the first time from the r...

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Bibliographic Details
Main Authors: Jang Hoon Kim, Ji Hyeon Park, Sung Cheol Koo, Yun-Chan Huh, Mok Hur, Woo Tae Park, Youn-Ho Moon, Tae Il Kim, Byoung Ok Cho
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Plants
Subjects:
<i>cis</i>-khellactone
soluble epoxide hydrolase
competitive inhibitor
molecular simulation
anti-inflammation
Online Access:https://www.mdpi.com/2223-7747/12/20/3656

Internet

https://www.mdpi.com/2223-7747/12/20/3656

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