Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala

Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala

Individuals with 22q11.2 deletion syndrome (22q11DS) are at high risk of developing psychiatric diseases such as schizophrenia. Individuals with 22q11DS and schizophrenia are impaired in emotional memory, anticipating, recalling, and assigning a correct context to emotions. The neuronal circuits res...

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Bibliographic Details
Main Authors: Tae-Yeon Eom, Ildar T. Bayazitov, Kara Anderson, Jing Yu, Stanislav S. Zakharenko
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
22q11.2 deletion
schizophrenia
thalamus
fear conditioning
active avoidance
dopamine receptors
microRNA processing
Dgcr8, emotional memory
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306083

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http://www.sciencedirect.com/science/article/pii/S2211124717306083

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