NMDAR activation attenuates the protective effect of BM-MSCs on bleomycin-induced ALI via the COX-2/PGE2 pathway

NMDAR activation attenuates the protective effect of BM-MSCs on bleomycin-induced ALI via the COX-2/PGE2 pathway

N-methyl-d-aspartate (NMDA) receptor (NMDAR) activation mediates glutamate (Glu) toxicity and involves bleomycin (BLM)-induced acute lung injury (ALI). We have reported that bone marrow-derived mesenchymal stem cells (BM-MSCs) are NMDAR-regulated target cells, and NMDAR activation inhibits the prote...

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Bibliographic Details
Main Authors: Xiao-Hong Li, Pu Huang, Hai-Peng Cheng, Yan Zhou, Dan-Dan Feng, Shao-Jie Yue, Yang Han, Zi-Qiang Luo
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023109315

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http://www.sciencedirect.com/science/article/pii/S2405844023109315

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