Protein Conformational Dynamics Underlie Selective Recognition of Thermophilic over Mesophilic Enzyme I by a Substrate Analogue

Protein Conformational Dynamics Underlie Selective Recognition of Thermophilic over Mesophilic Enzyme I by a Substrate Analogue

Substrate selectivity is an important preventive measure to decrease the possibility of cross interactions between enzymes and metabolites that share structural similarities. In addition, understanding the mechanisms that determine selectivity towards a particular substrate increases the knowledge b...

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Bibliographic Details
Main Authors: Aayushi Singh, Daniel Burns, Sergey L. Sedinkin, Brett Van Veller, Davit A. Potoyan, Vincenzo Venditti
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biomolecules
Subjects:
NMR
principal component analysis
ligand binding
drug discovery
selective inhibition
MD simulations
Online Access:https://www.mdpi.com/2218-273X/13/1/160

Internet

https://www.mdpi.com/2218-273X/13/1/160

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